Variational quantum algorithms (VQAs) are leading strategies to reach practical utilities of near-term quantum devices. However, the no-cloning theorem in quantum mechanics precludes standard backpropagation, leading to prohibitive quantum resource costs when applying VQAs to large-scale tasks. To address this challenge, we reformulate the training dynamics of VQAs as a nonlinear partial differential equation and propose a novel protocol that leverages physics-informed neural networks (PINNs) to model this dynamical system efficiently. Given a small amount of training trajectory data collected from quantum devices, our protocol predicts the parameter updates of VQAs over multiple iterations on the classical side, dramatically reducing quantum resource costs. Through systematic numerical experiments, we demonstrate that our method achieves up to a 30x speedup compared to conventional methods and reduces quantum resource costs by as much as 90\% for tasks involving up to 40 qubits, including ground state preparation of different quantum systems, while maintaining competitive accuracy. Our approach complements existing techniques aimed at improving the efficiency of VQAs and further strengthens their potential for practical applications.

Quantum federated learning (QFL) enables collaborative training of quantum machine learning (QML) models across distributed quantum devices without raw data exchange. However, QFL remains vulnerable to adversarial attacks, where shared QML model updates can be exploited to undermine information privacy. In the context of noisy intermediate-scale quantum (NISQ) devices, a key question arises: How can inherent quantum noise be leveraged to enforce differential privacy (DP) and protect model information during training and communication? This paper explores a novel DP mechanism that harnesses quantum noise to safeguard quantum models throughout the QFL process. By tuning noise variance through measurement shots and depolarizing channel strength, our approach achieves desired DP levels tailored to NISQ constraints. Simulations demonstrate the framework's effectiveness by examining the relationship between differential privacy budget and noise parameters, as well as the trade-off between security and training accuracy. Additionally, we demonstrate the framework's robustness against an adversarial attack designed to compromise model performance using adversarial examples, with evaluations based on critical metrics such as accuracy on adversarial examples, confidence scores for correct predictions, and attack success rates. The results reveal a tunable trade-off between privacy and robustness, providing an efficient solution for secure QFL on NISQ devices with significant potential for reliable quantum computing applications.

Transformer models and end-to-end learning frameworks are rapidly revolutionizing the field of artificial intelligence. In this work, we apply object detection transformers to analyze charge stability diagrams in semiconductor quantum dot arrays, a key task for achieving scalability with spin-based quantum computing. Specifically, our model identifies triple points and their connectivity, which is crucial for virtual gate calibration, charge state initialization, drift correction, and pulse sequencing. We show that it surpasses convolutional neural networks in performance on three different spin qubit architectures, all without the need for retraining. In contrast to existing approaches, our method significantly reduces complexity and runtime, while enhancing generalizability. The results highlight the potential of transformer-based end-to-end learning frameworks as a foundation for a scalable, device- and architecture-agnostic tool for control and tuning of quantum dot devices.

Quantum computing has significantly advanced in recent years, boasting devices with hundreds of quantum bits (qubits), hinting at its potential quantum advantage over classical computing. Yet, noise in quantum devices poses significant barriers to realizing this supremacy. Understanding noise's impact is crucial for reproducibility and application reuse; moreover, the next-generation quantum-centric supercomputing essentially requires efficient and accurate noise characterization to support system management (e.g., job scheduling), where ensuring correct functional performance (i.e., fidelity) of jobs on available quantum devices can even be higher-priority than traditional objectives. However, noise fluctuates over time, even on the same quantum device, which makes predicting the computational bounds for on-the-fly noise is vital. Noisy quantum simulation can offer insights but faces efficiency and scalability issues. In this work, we propose a data-driven workflow, namely QuBound, to predict computational performance bounds. It decomposes historical performance traces to isolate noise sources and devises a novel encoder to embed circuit and noise information processed by a Long Short-Term Memory (LSTM) network. For evaluation, we compare QuBound with a state-of-the-art learning-based predictor, which only generates a single performance value instead of a bound. Experimental results show that the result of the existing approach falls outside of performance bounds, while all predictions from our QuBound with the assistance of performance decomposition better fit the bounds. Moreover, QuBound can efficiently produce practical bounds for various circuits with over 106 speedup over simulation; in addition, the range from QuBound is over 10x narrower than the state-of-the-art analytical approach.

Quantum machine learning (QML) is a discipline that seeks to transfer the advantages of quantum computing to data-driven tasks. However, many studies rely on toy datasets or heavy feature reduction, raising concerns about their scalability. Progress is further hindered by hardware limitations and the significant costs of encoding dense vector representations on quantum devices. To address these challenges, we propose an efficient approach called Hamiltonian classifier that circumvents the costs associated with data encoding by mapping inputs to a finite set of Pauli strings and computing predictions as their expectation values. In addition, we introduce two classifier variants with different scaling in terms of parameters and sample complexity. We evaluate our approach on text and image classification tasks, against well-established classical and quantum models. The Hamiltonian classifier delivers performance comparable to or better than these methods. Notably, our method achieves logarithmic complexity in both qubits and quantum gates, making it well-suited for large-scale, real-world applications. We make our implementation available on GitHub.

Estimating the global Lipschitz constant of neural networks is crucial for understanding and improving their robustness and generalization capabilities. However, precise calculations are NP-hard, and current semidefinite programming (SDP) methods face challenges such as high memory usage and slow processing speeds. In this paper, we propose \textbf{HiQ-Lip}, a hybrid quantum-classical hierarchical method that leverages Coherent Ising Machines (CIMs) to estimate the global Lipschitz constant. We tackle the estimation by converting it into a Quadratic Unconstrained Binary Optimization (QUBO) problem and implement a multilevel graph coarsening and refinement strategy to adapt to the constraints of contemporary quantum hardware. Our experimental evaluations on fully connected neural networks demonstrate that HiQ-Lip not only provides estimates comparable to state-of-the-art methods but also significantly accelerates the computation process. In specific tests involving two-layer neural networks with 256 hidden neurons, HiQ-Lip doubles the solving speed and offers more accurate upper bounds than the existing best method, LiPopt. These findings highlight the promising utility of small-scale quantum devices in advancing the estimation of neural network robustness.

Quantum computing holds significant potential to accelerate machine learning algorithms, especially in solving optimization problems like those encountered in Support Vector Machine (SVM) training. However, current QUBO-based Quantum SVM (QSVM) methods rely solely on binary optimal solutions, limiting their ability to identify fuzzy boundaries in data. Additionally, the limited qubit count in contemporary quantum devices constrains training on larger datasets. In this paper, we propose a probabilistic quantum SVM training framework suitable for Coherent Ising Machines (CIMs). By formulating the SVM training problem as a QUBO model, we leverage CIMs' energy minimization capabilities and introduce a Boltzmann distribution-based probabilistic approach to better approximate optimal SVM solutions, enhancing robustness. To address qubit limitations, we employ batch processing and multi-batch ensemble strategies, enabling small-scale quantum devices to train SVMs on larger datasets and support multi-class classification tasks via a one-vs-one approach. Our method is validated through simulations and real-machine experiments on binary and multi-class datasets. On the banknote binary classification dataset, our CIM-based QSVM, utilizing an energy-based probabilistic approach, achieved up to 20% higher accuracy compared to the original QSVM, while training up to $10^4$ times faster than simulated annealing methods. Compared with classical SVM, our approach either matched or reduced training time. On the IRIS three-class dataset, our improved QSVM outperformed existing QSVM models in all key metrics. As quantum technology advances, increased qubit counts are expected to further enhance QSVM performance relative to classical SVM.

The recent advancements in noisy intermediate-scale quantum (NISQ) devices implementation allow us to study their application to real-life computational problems. However, hardware challenges are not the only ones that hinder our quantum computation capabilities. Software limitations are the other, less explored side of this medal. Using satellite image segmentation as a task example, we investigated how difficult it is to run a hybrid quantum-classical model on a real, publicly available quantum device. We also analyzed the costs of such endeavor and the change in quality of model.